How Do Safety Features Compare Between LiFePO4 and Lithium-Ion Batteries? LiFePO4 (lithium iron phosphate) batteries are inherently safer due to their stable chemical structure, which minimizes thermal runaway risks. Lithium-ion batteries (e.g., NMC, LCO) use… LiFePO4 vs. Lithium Ion Batteries: What’s the Best Choice for Your Needs?